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研究人員使用RZ-2994來表征抑製SHMT1/2在T細胞急性淋巴細胞白血病 (T-ALL) 中的作用,RZ-2994通過必威betway网址定製合成

2023-07-05
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45.jpgDespite progress in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) has limited treatment options, particularly in the setting of relapsed/refractory disease. Researchers used SHMT1/2 inhibitor RZ-2994 to characterize the effect of inhibiting SHMT1/2 in T-ALL. 

Loss of both SHMT1/2 is necessary for impaired growth and cell cycle arrest, with suppression of SHMT1/2 inhibiting leukemia progression. RZ-2994 also decreases leukemia burden in vivo. RZ-2994 was obtained from Medicilon.

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